The nation’s most populous state is ordering its nearly 40 million residents to stay home to prevent the spread of the coronavirus.

California Gov. Gavin Newsom’s order marks the first statewide mandatory restrictions issued in the United States to help combat the outbreak. It goes into effect Thursday at midnight and includes exemptions for essential services such as public safety and medical care. Nineteen people have died and more than 900 have tested positive for coronavirus in California. The restrictions, which will remain in place until further notice, come a day after Newsom warned that more than half the state is projected to be infected with the virus in two months.

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